U.S., March 5 -- ClinicalTrials.gov registry received information related to the study (NCT06856252) titled 'Human Liver ORganoids as a Model to Study the Development of Non-Alcoholic SteatOhepatitis (NASH)' on March 08, 2024.
Brief Summary: The primary objective of the study is to generate and characterize three-dimensional models, called "assembloids", composed of the main liver cell populations (in particular from the co-culture of organoids with stellate cells, responsible for fibrogenesis, deriving from clinical samples). These models will be used in order to imitate the first phases of the onset of steatohepatitis, in conditions of altered lipid metabolism (induced through exposure to the main environmental determinants of this condi...