U.S., May 22 -- ClinicalTrials.gov registry received information related to the study (NCT06982768) titled 'How Epigenetic Changes in hMLH1 Connect Lab Research With Diagnosis in Gastric Cancer' on May 05.
Brief Summary: DNA methylation is one of the key mechanisms that are thought to underlie the association between aging and cancer. Several methylation-based measures of biological aging have been developed and have demonstrated an association with mortality and, in some cases, with cancer incidence. Accordingly, CpG promoter hypermethylation is a well-known mechanism of gene inactivation in carcinogenesis.
Gastric cancer has been classified in different molecular phenotypes based on genetic and epigenetic characteristics. One of these s...