Clinical Trial: HBV-Specific TCR-T Cell Therapy Combined with Nucleos(t)ide Analogues (NAs) in Chronic Hepatitis B Patients

U.S., March 21 -- ClinicalTrials.gov registry received information related to the study (NCT06885710) titled 'HBV-Specific TCR-T Cell Therapy Combined with Nucleos(t)ide Analogues (NAs) in Chronic Hepatitis B Patients' on March 14.

Brief Summary: This is a open-label study to evaluate the safety and efficacy of autologous T-cells transfected with mRNA encoding Hepatitis-B virus (HBV) antigen specific T cell receptor (TCR) in combination with nucleos(t)ide analogues (NAs) in HBeAg-positive chronic hepatitis B patients.

Study Start Date: Jan. 01

Study Type: INTERVENTIONAL

Condition: Chronic Hepatitis B

Intervention: BIOLOGICAL: LioCyx-M

Each patient will receive LioCyx-M infusion every two weeks, while continuing their existing nucleo...