Clinical Trial: Glucagon Resistance in Patients With MASLD and T2DM

U.S., Nov. 25 -- ClinicalTrials.gov registry received information related to the study (NCT07246421) titled 'Glucagon Resistance in Patients With MASLD and T2DM' on Nov. 17.

Brief Summary: The goal of this clinical trial is to investigate the sensitivity to glucagon in patients with type 2 diabetes mellitus (T2DM), with and without metabolic associated fatty liver disease (MASLD).

The main questions it aims to answer are:

1. Is the sensitivity to glucagon with respect to hepatic FA oxidation and suppression of VLDL-TG secretion impaired in humans with T2DM and MASLD?

2. Is glucagon resistance and MASLD reflected in an aberrated lipidomic/metabolomic profile in blood and adipose tissue?

Researchers will compare patients with T2DM with a...