U.S., Jan. 3 -- ClinicalTrials.gov registry received information related to the study (NCT07314814) titled 'Genetic Hallmarks of Patients With Congenital Portosystemic Shunts and Portopulmonary Hypertension' on Dec. 18, 2025.
Brief Summary: Congenital portosystemic shunt (CPSS) are rare vascular malformations causing blood from the intestines to bypass the liver and directly flow into body's general circulation. Such liver bypass can cause several health problems, one of the most severe being portopulmonary hypertension (PoPH).
The goal of this study is to identify pathogenic and potentially pathogenic genetic variants in patients who have both CPSS and PoPH. In future research studies, we will investigate if these genetic changes contrib...