Clinical Trial: Exploring Sympathetic Nervous System Function in Individuals With Down Syndrome

U.S., Nov. 21 -- ClinicalTrials.gov registry received information related to the study (NCT07238465) titled 'Exploring Sympathetic Nervous System Function in Individuals With Down Syndrome' on Oct. 22.

Brief Summary: Down syndrome (DS), the most common genetic cause of intellectual disability, is associated with widespread organ dysfunction, including abnormalities in the autonomic nervous system (ANS). The ANS regulates critical functions such as heart rate (HR) and blood pressure (BP), both essential for maintaining homeostasis and supporting physical activity. Individuals with DS often exhibit blunted HR responses to exercise-typically ~30 beats per minute below expected levels-suggesting reduced sympathetic nervous system (SNS) activit...