U.S., July 30 -- ClinicalTrials.gov registry received information related to the study (NCT07091136) titled 'Exploration of Manidipine to Reverse Aortic Valve Calcification' on July 21.

Brief Summary: This is a prospective, randomized, comparative, clinical trial conducted by Wuhan Union Hospital that aims to evaluate the efficacy and safety of manidipine compared to placebo in patients with calcific aortic valve disease with mild aortic valve stenosis.

Study Start Date: Aug. 01

Study Type: INTERVENTIONAL

Condition: Calcific Aortic Valve Disease

Intervention: DRUG: manidipine

study will enrol 100 adults aged 60 to 85 years with MDCT-confirmed mild-to-moderate aortic valve calcification (Agatston score 300-2 000 AU) and preserved lef...