U.S., March 20 -- ClinicalTrials.gov registry received information related to the study (NCT06883175) titled 'Evolution of the Chicago Classification: Bridging Physiology and Mechanics' on Nov. 25, 2024.
Brief Summary: Swallowing difficulties are extremely common and result in substantial morbidity, reduction in the quality of life, and mortality related to malnutrition and complications from regurgitation and aspiration. Unfortunately, our understanding regarding the pathophysiology of dysphagia and GERD has been hampered by focusing predominantly on circular muscle activity and ignoring the essential biomechanical properties of the esophageal wall that promote normal emptying. Our initial work explored the relationship between intrabolus...