Clinical Trial: Evaluating Urinary Microbiome Modulation :An RCT of Antibiotic vs Gynoflor Prophylaxis in Postmenopausal Women With Recurrent Cystitis

U.S., Sept. 23 -- ClinicalTrials.gov registry received information related to the study (NCT07186465) titled 'Evaluating Urinary Microbiome Modulation :An RCT of Antibiotic vs Gynoflor Prophylaxis in Postmenopausal Women With Recurrent Cystitis' on Sept. 15.

Brief Summary: This randomized controlled trial will compare two ways to prevent recurrent urinary tract infection (rUTI) in postmenopausal women: (1) nightly oral nitrofurantoin and (2) a vaginal tablet containing Lactobacillus with ultra-low-dose estriol (Gynoflor). The study also tracks how each strategy changes the urinary microbiome. Participants are randomized 1:1 in computer-generated blocks; the trial is open-label and follows patients for 6 months.

Women >=40 years with rUTI ...