U.S., June 19 -- ClinicalTrials.gov registry received information related to the study (NCT07027020) titled 'Efficacy of Intravesical Oxybutynin in Children With Neurogenic Bladder Dysfunction' on May 22.
Brief Summary: Malformation of the lumbosacral region (spina bifida) affects the innervation of the bladder in children. The usual evolution leads to a neurological bladder with small capacity, poor compliancy and overactivity, exposing to incontinence and obstruction to the evacuation of urine. It is responsible for renal failure requiring dialysis and transplantation. Current therapeutics aim to evacuate urine and reduce intravesical pressure. It gradually combines 1) intermittent catheterization, 2) anticholinergics, 3) botulinum toxin...