U.S., Jan. 9 -- ClinicalTrials.gov registry received information related to the study (NCT07328100) titled 'Efficacy and Safety of Coenzyme I for Injection on Vascular Aging.' on Dec. 28, 2025.
Brief Summary: Emerging evidence identifies vascular aging independently predicting cardiovascular events, yet effective clinical interventions remain lacking. Nicotinamide adenine dinucleotide (NAD+) is an essential cofactor whose levels decline with age, and preclinical studies suggest that boosting NAD+ can improve vascular function and structure. Preliminary clinical studies in healthy older adults indicate that supplementation with NAD+ precursors, such as nicotinamide riboside(NR) or nicotinamide mononucleotide (NMN), can reduce arterial stiff...