U.S., July 16 -- ClinicalTrials.gov registry received information related to the study (NCT07066306) titled 'Effects of Local Ketamine in Orthognathic Procedures' on June 23.
Brief Summary: Orthognathic surgery is performed to correct congenital, developmental, or trauma-related skeletal deformities of the maxilla and mandible. These procedures involve multiple incisions, dissections, and osteotomies, leading to significant postoperative inflammatory responses and acute pain. Postoperative pain is a key factor influencing recovery, return to function, and length of hospital stay.
Various analgesics have been used to manage pain after orthognathic surgery, including NSAIDs, opioids, acetaminophen, NMDA receptor antagonists, and long-acting...