Clinical Trial: Effects of E-Cigarette Use on Oxidative Stress and Matrix Degradation

U.S., Jan. 14 -- ClinicalTrials.gov registry received information related to the study (NCT07338318) titled 'Effects of E-Cigarette Use on Oxidative Stress and Matrix Degradation' on Jan. 03.

Brief Summary: This cross-sectional observational study aims to investigate the effects of e-cigarette use on oxidative and matrix-degrading pathways in periodontally healthy individuals. Gingival crevicular fluid biomarkers, including matrix metalloproteinase-9 (MMP-9), reactive oxygen species (ROS), and forkhead-box-1 (FOXO1), will be analyzed to compare the biochemical and inflammatory responses among three groups: e-cigarette users, conventional cigarette smokers, and non-smokers. The study seeks to clarify whether e-cigarette use induces subclini...