U.S., June 25 -- ClinicalTrials.gov registry received information related to the study (NCT07034560) titled 'Effectiveness of Oral Melatonin vs Oral Tranexamic Acid in the Treatment and Recurrence of Melasma' on June 10.
Brief Summary: This study compares the effectiveness of two oral medications-melatonin and tranexamic acid -in treating melasma, a common skin condition that causes dark facial patches.
Participants will be randomly assigned to receive either melatonin, tranexamic acid, or a placebo once daily at bedtime for 12 weeks. During this treatment phase, all participants will also apply a broad-spectrum sunscreen and a base cream.
After 12 weeks, participants will stop the oral medication but continue using the sunscreen and bas...