U.S., Sept. 27 -- ClinicalTrials.gov registry received information related to the study (NCT07194304) titled 'Effect of Parenteral Alpha-Tocopherol in the Definitive Surgery of Tetralogy of Fallot' on July 04.
Brief Summary: Introduction:
Tetralogy of Fallot (ToF) correction with cardiopulmonary bypass (CPB) poses a risk of ischemia-reperfusion injury, especially in cyanotic myocardium. Alpha-tocopherol, a potent antioxidant, may reduce myocardial damage during surgery.
Methods:
This randomized controlled trial included 58 ToF patients aged 1-10 years undergoing definitive surgery with CPB at Integrated Heart Center, Cipto Mangunkusumo Hospital. Patients were randomly assigned to receive either parenteral alpha-tocopherol (4 mg/kg) or p...