U.S., April 17 -- ClinicalTrials.gov registry received information related to the study (NCT06930391) titled 'Effect of Extracellular Calcium on Carbetocin Mediated Contractility in Human Myometrium' on April 09.
Brief Summary: Postpartum hemorrhage (PPH) continues to be an increasing problem globally. Uterotonics play an essential role in the pharmacological management of uterine atony. Carbetocin, a long acting analog of oxytocin has been recommended as a first line uterotonic for PPH prophylaxis at cesarean delivery. Considering many woman have associated comorbidities and are at high risk of PPH, finding alternative pharmacological agents is essential. Calcium is a key factor for myometrial contractions and calcium blood levels can be ...