U.S., Jan. 8 -- ClinicalTrials.gov registry received information related to the study (NCT07324499) titled 'Effect of Dexamethasone on Plasma Levels of Bupivacaine and Dexamethasone After a Single-injection Interscalene Nerve Block.' on Dec. 05, 2025.
Brief Summary: Recent studies have highlighted the comparative advantages of perineural dexamethasone, particularly regarding its safety profile and its ability to prolong analgesia in various peripheral nerve blocks. A recent systematic review demonstrated that perineural administration of dexamethasone significantly extends the duration of analgesia compared to intravenous administration.
The mechanism of action of perineural dexamethasone remains unclear. Moreover, there is a lack of rese...