U.S., March 21 -- ClinicalTrials.gov registry received information related to the study (NCT06887062) titled 'Dual Endothelin Receptor Antagonism in Large Vessel Vasculitis (DERAIL-LVV)' on March 13.
Brief Summary: Large vessel vasculitis is a disease that causes damage to blood vessels. This damage to blood vessels can increase the risk of patients with LVV developing cardiovascular disease, including heart attacks and strokes. A chemical produced in the body called endothelin may contribute to this increase in cardiovascular disease risk by causing the vessels to stiffen and blood pressure to increase.
It has previously been shown that by blocking the effects of endothelin, vessel stiffness and blood pressure improve. Bosentan is a tabl...