U.S., Jan. 15 -- ClinicalTrials.gov registry received information related to the study (NCT07341854) titled 'Dexamethasone Palmitate for Postoperative Pain' on Dec. 14, 2025.
Brief Summary: Postoperative pain remains highly prevalent and inadequately managed in a significant proportion of surgical patients, often leading to delayed recovery, increased opioid consumption, and potential progression to chronic pain. While perioperative systemic dexamethasone is used for its anti-inflammatory and opioid-sparing effects, its efficacy is inconsistent, and concerns regarding systemic side effects persist. Dexamethasone palmitate, a novel lipophilic prodrug formulated as nanoparticle emulsion, leverages the enhanced permeability and retention effe...