U.S., Dec. 6 -- ClinicalTrials.gov registry received information related to the study (NCT07266337) titled 'CD19/BCMA CAR-T for SLE' on Nov. 23.
Brief Summary: The purpose of this clinical trial is to learn if CD19/BCMA CAR-T works to treat refractory SLE in adults. It will also learn about the safety and efficacy of the CD19/BCMA CAR-T cell product.
The main questions it aims to answer are:
1. What CAR-T-related adverse events (AEs) occur within 3 months after the CAR-T cell infusion?
2. Which dose level is the optimal biological dose (OBD)?
3. What is the the changes of disease activity status, proportion of patients achieving DORIS remission, percentage of participants achieving maintenance of drug-free DORIS remission, proportion o...