U.S., Jan. 7 -- ClinicalTrials.gov registry received information related to the study (NCT07318948) titled 'BALANCE Trial Domain Within the ACT-GLOBAL Adaptive Platform Trial-NCT06352632' on Dec. 08, 2025.
Brief Summary: Elevated blood pressure (BP) is nearly universal in acute ischemic stroke (AIS) and critically influences eligibility for intravenous thrombolysis; however, current guidelines-requiring BP reduction to below 185/110 mmHg before treatment-lack robust evidence and may delay reperfusion in a time-sensitive therapy, potentially worsening outcomes. Emerging data suggest that aggressive pre-thrombolysis BP lowering does not reduce hemorrhage risk and might impair recovery, highlighting the need to avoid large BP fluctuations. Ye...