Clinical Trial: Antidepressant Response of DMT Masked With Propofol

U.S., April 16 -- ClinicalTrials.gov registry received information related to the study (NCT06927076) titled 'Antidepressant Response of DMT Masked With Propofol' on April 04.

Brief Summary: The aim of this study is to elucidate if the anti-depressive effect of N,N-dimethyltryptamine (DMT) is based on a biological mechanisms including neuroplasticity and anti-inflammatory effect or due to the subjective psychedelic experience.

Study Start Date: April, 2025

Study Type: INTERVENTIONAL

Condition: Major Depressive Disorder Psychedelic Experiences

Intervention: DRUG: N,N-Dimethyltryptamine

administration of a 2mg/min DMT perfusion over 20 min

DRUG: Placebo

administration of a placebo perfusion over 20 min

PROCEDURE: Propofol

30 min p...