Clinical Trial: An Open Label Phase 2 Study of Total Neoadjuvant Therapy (TNT) Consisting of FLOT With Pembrolizumab and Short Radiation for Patients With Locally Advanced Gastroesophageal Junction Adenocarcinoma

U.S., June 13 -- ClinicalTrials.gov registry received information related to the study (NCT07018570) titled 'An Open Label Phase 2 Study of Total Neoadjuvant Therapy (TNT) Consisting of FLOT With Pembrolizumab and Short Radiation for Patients With Locally Advanced Gastroesophageal Junction Adenocarcinoma' on June 04.

Brief Summary: This study is to evaluate the effectiveness of treatment for esophagogastric junction carcinoma, total neoadjuvant therapy (TNT) including pembrolizumab and FLOT is conducted, aiming to choose between surgery or organ preservation treatment strategies.

Study Start Date: June, 2025

Study Type: INTERVENTIONAL

Condition: Gastroesophageal Junction (GEJ) Adenocarcinoma

Intervention: DRUG: Pembrolizumab

Pembrol...