U.S., March 20 -- ClinicalTrials.gov registry received information related to the study (NCT06884514) titled 'Acute Effects of MDMA Co-administration on the Response to Psilocybin in Healthy Subjects' on Jan. 31.
Brief Summary: The acute subjective effects of serotonin (5-HT)2A receptor stimulation with psilocybin in humans are mostly positive. However, negative effects such as anxiety, paranoid thinking, or loss of trust towards other people are common effects, depending on the dose administered, the personality traits of the person consuming it (set), or the environment in which psilocybin is taken (setting). Negative psychedelic effects may cause acute distress to the subject and acute anxiety has been linked to less favorable long-term...