Clinical Trial: Accelerated Versus Standard Initiation of Continuous Veno-Venous Hemodiafiltration Following Hemoperfusion in Severe Acute Diquat Poisoning

U.S., May 14 -- ClinicalTrials.gov registry received information related to the study (NCT06966765) titled 'Accelerated Versus Standard Initiation of Continuous Veno-Venous Hemodiafiltration Following Hemoperfusion in Severe Acute Diquat Poisoning' on May 04.

Brief Summary: Diquat (1,1'-ethylene-2,2'-bipyridinium) is a bipyridine herbicide that shares a similar physicochemical structure and redox cycling mechanism with paraquat. Upon ingestion, it is rapidly absorbed and distributed to gastrointestinal tract, kidneys, liver, skeletal muscle, lungs, myocardium, and central nervous systems. Patients with severe diquat poisoning often develop toxic encephalopathy, circulatory collapse, and multi-organ dysfunction. Extracorporeal treatments, i...