U.S., Jan. 28 -- ClinicalTrials.gov registry received information related to the study (NCT06794125) titled 'A Phase II/III Randomized Evaluation of Dose-escalation with Esophageal-sparing for Palliation of Intrathoracic Tumours (PREVENT)' on Jan. 21.
Brief Summary: This is a pragmatic trial with patients randomized between standard of care palliative thoracic radiation therapy (RT) vs. hypofractionated, dose-escalated, esophageal-sparing (HD-ES) intensity modulated radiation therapy (IMRT).
We hypothesize that the use of advanced radiation planning techniques to optimize dose to esophagus will permit the safe delivery of a modestly dose-escalated five-fraction course of palliative radiation to intrathoracic malignancies. This approach ai...