U.S., Feb. 24 -- ClinicalTrials.gov registry received information related to the study (NCT07427472) titled '"Detection and Follow-up of Coronary Lesions in HeFH (DESTINY-FH Study)"' on Aug. 14, 2025.
Brief Summary: This multicenter, non-randomized interventional study aims to assess coronary artery disease progression over 5 years in patients with genetically confirmed heterozygous familial hypercholesterolemia (HeFH), using coronary computed tomography angiography (CCTA).
The primary endpoint is the visual evaluation of coronary stenosis using CAD-RADS v2.0, identifying changes between baseline (2018-2022) and study inclusion. The study will enroll 300 patients (100 protected, 200 non-protected) from La Pitie-Salpetriere hospital and Sa...