U.S., Jan. 28 -- ClinicalTrials.gov registry received information related to the study (NCT06794372) titled '[68Ga]Ga-FAPI-46 in Staging of Head and Neck Carcinomas' on Dec. 24, 2024.
Brief Summary: The trial focuses on assessing the role of [68Ga]Ga-FAPI-46 in head and neck squamous cell carcinomas (HNSCC) staging before surgery. In the context of metastasis, cancer-associated fibroblasts (CAFs) emerge as pivotal contributors to the creation of a microenvironment conducive to future metastases. CAFs exert their influence through intricate mechanisms, including the remodeling of the extracellular matrix by secreting proteins such as collagen and fibronectin. This process enhances the structural support for cancer cell invasion into adjacen...