ALEXANDRIA, Va., June 10 -- United States Patent no. 12,291,515, issued on May 6, was assigned to Zheming Wang (Hangzhou, China) and Rushi Biotech (Hangzhou) Co. Ltd (Hangzhou, China).

"Pyrrolidine derivative and use thereof" was invented by Zheming Wang (Hangzhou, China) and Hao Tan (Hangzhou, China).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention discloses a pyrrolidine derivative or its optically active isomer, or a pharmaceutically acceptable salt thereof, which is useful as an NAMPT inhibitor, and useful as a potential agent for the chemotherapy of a variety of diseases associated with abnormal NAD+ expression. The pyrrolidine derivative has pyrrolidine as a parent structure, to whic...