ALEXANDRIA, Va., Sept. 17 -- United States Patent no. 12,415,800, issued on Sept. 16, was assigned to Zhejiang Tianyu Pharmaceutical Co. Ltd. (China).
"Preparation method for losartan" was invented by Zuwei He (Zhejiang, China), Gang Liu (Zhejiang, China), Dequan Su (Zhejiang, China), Ruiyun Lv (Zhejiang, China), Wei Xiao (Zhejiang, China), Zhen Wang (Zhejiang, China), Guorong Zhu (Zhejiang, China) and Yongjun Tu (Zhejiang, China).
According to the abstract* released by the U.S. Patent & Trademark Office: "Provided is a preparation method of losartan, which is prepared by reacting a cyano group-containing intermediate represented by formula (I) with an azide reagent in toluene in the presence of a catalyst; wherein, after the reaction is ...