ALEXANDRIA, Va., Dec. 16 -- United States Patent no. 12,497,589, issued on Dec. 16, was assigned to Zhejiang Seedling Biotechnology Co. Ltd (Hangzhou, China).
"Ergothioneine-producing engineered bacteria and construction method and use thereof" was invented by Maoxing Luo (Hangzhou, China) and Tianyi Wang (Hangzhou, China).
According to the abstract* released by the U.S. Patent & Trademark Office: "Ergothioneine-producing engineered bacteria and a construction method and use thereof are provided. The construction method includes: integrating a constitutive promoter PrrnD and an ergothioneine-synthesizing gene cluster egtABCDE derived from Mycolicibacterium neoaurum into a genome of Escherichia coli as a starting strain; and further mutati...