ALEXANDRIA, Va., Dec. 2 -- United States Patent no. 12,486,283, issued on Dec. 2, was assigned to YONSUNG FINE CHEMICAL Co. LTD. (Hwaseong-si, South Korea).
"Crystalline salt of eribulin" was invented by Areum Baek (Suwon-si, South Korea), Hyunik Shin (Suwon-si, South Korea), Yongseo Park (Suwon-si, South Korea), Seongtaek Kim (Suwon-si, South Korea) and Seunghui Sin (Suwon-si, South Korea).
According to the abstract* released by the U.S. Patent & Trademark Office: "An eribulin salt formed by combining an eribulin free base with a low molecular weight amine compound through a diacid compound is disclosed. As the diacid compound, edisylic acid, 1,5-naphthalenedisulfonic acid, trans-2-butene-1,4-dicarboxylic acid, pyrophosphoric acid, and c...