US Patent Issued to YALE UNIVERSITY on Oct. 14 for "Compositions and methods for enhancing donor oligonucleotide-based gene editing" (Connecticut, Massachusetts Inventors)

ALEXANDRIA, Va., Oct. 21 -- United States Patent no. 12,441,814, issued on Oct. 14, was assigned to YALE UNIVERSITY (New Haven, Conn.).

"Compositions and methods for enhancing donor oligonucleotide-based gene editing" was invented by Elias Quijano (Durham, Conn.), Audrey Turchick (Chelmsford, Mass.) and Peter Glazer (Guilford, Conn.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Compositions for enhanced gene editing and methods of use thereof are. The composition contains a cell-penetrating antibody and a donor oligonucleotide containing a sequence that can correct a mutation in a cell's genome. Preferably, the composition does not contain a nuclease, PNA, or nanoparticle. The compositions are used to modif...