US Patent Issued to Yale University on Jan. 27 for "Mutant fibroblast growth factor 21 (FGF21) polypeptides" (Connecticut Inventors)

ALEXANDRIA, Va., Jan. 28 -- United States Patent no. 12,534,503, issued on Jan. 27, was assigned to Yale University (New Haven, Conn.).

"Mutant fibroblast growth factor 21 (FGF21) polypeptides" was invented by Joseph Schlessinger (New Haven, Conn.) and Sangwon Lee (New Haven, Conn.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Described herein soluble polypeptide comprising a FGF21 variant. The FGF21 variant comprises amino acid residues 29-209 of SEQ ID NO: 3, except that two or more amino acid residues in 29-209 of SEQ ID NO: 3 are mutated with respect to SEQ ID NO:3. The FGF21 variant comprises at least mutations L194F and R203W with respect to SEQ ID NO:3. Also described is a method of treating or ameli...