US Patent Issued to YALE UNIVERSITY on Dec. 2 for "Bifunctional small molecules to target the selective degradation of circulating proteins" (Connecticut, New York Inventors)

ALEXANDRIA, Va., Dec. 2 -- United States Patent no. 12,485,178, issued on Dec. 2, was assigned to YALE UNIVERSITY (New Haven, Conn.).

"Bifunctional small molecules to target the selective degradation of circulating proteins" was invented by David Spiegel (New Haven, Conn.), David Caianiello (Brooklyn, N.Y.) and Mengwen Zhang (New Haven, Conn.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure is directed to bifunctional small molecules which contain a circulating protein binding moiety (CPBM) linked through a linker group to a cellular receptor binding moiety (CRBM) which is a membrane receptor of degrading cell such as a hepatocyte or other degrading cell. In certain embodiments, the (CRB...