US Patent Issued to Yale University on Dec. 16 for "Compositions and methods for treating sickle cell disease" (Connecticut Inventors)

ALEXANDRIA, Va., Dec. 16 -- United States Patent no. 12,496,357, issued on Dec. 16, was assigned to Yale University (New Haven, Conn.).

"Compositions and methods for treating sickle cell disease" was invented by Peter Glazer (Guilford, Conn.), Elias Quijano (Durham, Conn.), W. Mark Saltzman (New Haven, Conn.) and Hee Won Suh (New Haven, Conn.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Peptide nucleic acid (PNA) oligomers that target the Beta-globin gene and can increase the frequency of recombination of donor oligonucleotide at the site of a Sickle Cell Disease mutation are provided. Nanoparticle formulations for delivering the PNA oligomers and donor oligonucleotides, and potentiating agents for increas...