US Patent Issued to Yale University on Dec. 16 for "Compositions and methods for high-throughput activation screening to boost T cell effector function" (Connecticut, California, Illinois Inventors)

ALEXANDRIA, Va., Dec. 16 -- United States Patent no. 12,497,611, issued on Dec. 16, was assigned to Yale University (New Haven, Conn.).

"Compositions and methods for high-throughput activation screening to boost T cell effector function" was invented by Sidi Chen (Milford, Conn.), Ryan D. Chow (San Jose, Calif.), Lupeng Ye (New Haven, Conn.), Matthew Dong (San Francisco), Jonathan Park (Scott AFB, Ill.) and Lei Peng (New Haven, Conn.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention includes dead-guide RNA (dgRNA) libraries and methods of use in immunology and immunotherapy thereof. Also provided are engineered primary or chimeric antigen receptor (CAR) T cells that overexpress Prodh2, Ccn...