US Patent Issued to XLIFESC on July 1 for "High-affinity TCR for NY-ESO" (Chinese Inventors)

ALEXANDRIA, Va., July 3 -- United States Patent no. 12,344,652, issued on July 1, was assigned to XLIFESC LTD. (Guangdong, China).

"High-affinity TCR for NY-ESO" was invented by Yi Li (Guangdong, China) and Jinhua Huang (Guangdong, China).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided is a T cell receptor (TCR) having a property of binding to a SLLMWITQC (SEQ ID NO: 105)-HLA A2 complex; and the binding affinity of the TCR to the SLLMWITQC (SEQ ID NO: 105)-HLA A2 complex is at least twice that of a wild-type TCR to the SLLMWITQC (SEQ ID NO: 105)-HLA A2 complex. Also provided is a fusion molecule of such a TCR with a therapeutic agent. Such a TCR can be used alone or in combination with a therapeutic a...