ALEXANDRIA, Va., June 5 -- United States Patent no. 12,275,773, issued on April 15, was assigned to XLIFESC LTD. (Guangdong, China).
"High affinity cell receptor for recognizing AFP antigen" was invented by Yi Li (Guangdong, China), Xiaolin Li (Guangdong, China) and Shaopei Chen (Guangdong, China).
According to the abstract* released by the U.S. Patent & Trademark Office: "Provided in the present invention is a T cell receptor (TCR) having the property of binding to a FMNKFIYEI-HLA A0201 complex; and the binding affinity of the TCR to the FMNKFIYEI-HLA A0201 complex is at least 2 times the binding affinity of the wild-type TCR to the FMNKFIYEI-HLA A0201 complex. Also provided in the present invention is a fusion molecule of such TCRs with...