US Patent Issued to Xencor on Nov. 11 for "Heterodimeric human IgG1 polypeptides with isoelectric point modifications" (California Inventors)

ALEXANDRIA, Va., Nov. 11 -- United States Patent no. 12,466,897, issued on Nov. 11, was assigned to Xencor Inc. (Pasadena, Calif.).

"Heterodimeric human IgG1 polypeptides with isoelectric point modifications" was invented by Gregory L. Moore (Monrovia, Calif.) and Gregory Lazar (Pacifica, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The invention relates generally to compositions and methods for purifying the desired species from a mixture of desired heterodimer and contaminating homodimer immunoglobulin variants by modifying the isoelectric point(s) of the individual chains."

The patent was filed on March 21, 2025, under Application No. 19/087,398.

*For further information, including images, char...