US Patent Issued to Wisconsin Alumni Research Foundation on April 22 for "Engineered biocatalysts for the synthesis of gamma-hydroxy amino acids" (Wisconsin Inventors)

ALEXANDRIA, Va., June 6 -- United States Patent no. 12,281,341, issued on April 22, was assigned to Wisconsin Alumni Research Foundation (Madison, Wis.).

"Engineered biocatalysts for the synthesis of gamma-hydroxy amino acids" was invented by Andrew R. Buller (Madison, Wis.), Jonathan M. Ellis (Madison, Wis.) and Prasanth Kumar (Madison, Wis.).

According to the abstract* released by the U.S. Patent & Trademark Office: "A DNA expression construct comprising a polynucleotide encoding an unnatural UstD enzyme, the unnatural enzyme itself, and a method of making gamma-hydroxy amino acids by contacting an aldehyde-containing substrate, an amino acid, and the unnatural, purified UstD enzyme under conditions and for a time sufficient to react at...