US Patent Issued to Wisconsin Alumni Research Foundation (WARF) on Sept. 9 for "Human pluripotent stem cell-based screening for smooth muscle cell differentiation and disease" (Wisconsin Inventors)

ALEXANDRIA, Va., Sept. 10 -- United States Patent no. 12,410,404, issued on Sept. 9, was assigned to Wisconsin Alumni Research Foundation (WARF) (Madison, Wis.).

"Human pluripotent stem cell-based screening for smooth muscle cell differentiation and disease" was invented by James A. Thomson (Madison, Wis.) and Jue Zhang (Madison, Wis.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Methods of using a small molecule MYH11 agonist to inhibit intimal hyperplasia and to maintain a contractile phenotype in vitro and in vivo are described. Also described herein are methods for generating human contractile smooth muscle cells from human pluripotent stem cells under defined conditions in the presence of the small mol...