US Patent Issued to WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH on March 18 for "Compositions and methods for making epigenetic modifications" (Massachusetts Inventors)

ALEXANDRIA, Va., March 19 -- United States Patent no. 12,252,715, issued on March 18, was assigned to WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (Cambridge, Mass.).

"Compositions and methods for making epigenetic modifications" was invented by Edwin Neumann (Somerville, Mass.), Tessa Bertozzi (Cambridge, Mass.) and Jonathan Weissman (Cambridge, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The disclosure provides, in various embodiments, fusion proteins comprising a DNA-binding domain, a DNMT3A-binding domain, and a H3K4me0; and polynucleotides and vectors encoding one or more of the fusion proteins. The disclosure also provides, in various embodiments, gene-delivery systems, cells, compositions (e.g...