US Patent Issued to Wayne State University on July 1 for "AAV-mediated subcellular targeting of heterologous rhodopsins in retinal ganglion cells" (Michigan Inventor)

ALEXANDRIA, Va., July 3 -- United States Patent no. 12,343,408, issued on July 1, was assigned to Wayne State University (Detroit).

"AAV-mediated subcellular targeting of heterologous rhodopsins in retinal ganglion cells" was invented by Zhuo-Hua Pan (Troy, Mich.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Microbial type rhodopsins, such as the light-gated cation-selective membrane channel, channelrhodopsin-2 (Chop2/ChR2) or the ion pump halorhodopsin (HaloR) are expressed in retinal ganglion cells upon transduction using recombinant AAV vectors. Selective targeting of these transgenes for expression in discrete subcellular regions or sites is achieved by including a sorting motif in the vector that can t...