US Patent Issued to Washington University on May 20 for "Suppression of cytokine release syndrome in chimeric antigen receptor cell therapy" (Missouri Inventors)

ALEXANDRIA, Va., June 16 -- United States Patent no. 12,304,941, issued on May 20, was assigned to Washington University (St. Louis).

"Suppression of cytokine release syndrome in chimeric antigen receptor cell therapy" was invented by John DiPersio (St. Louis), Matthew Cooper (St. Louis) and Alun Carter (St. Louis).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed herein are methods of gene editing, or endogenous suppression, of cytokines/chemokines/transcription factors secreted from chimeric antigen receptor (CAR)-bearing immune effector cell such as CAR-T cells for the mitigation of cytokine release syndrome and/or CAR-T associated neuropathy. These methods involve insertion of the CAR into a locus ...