US Patent Issued to Vertex Pharmaceuticals on Dec. 16 for "Compositions and methods for editing beta-globin for treatment of hemaglobinopathies" (Massachusetts Inventors)

ALEXANDRIA, Va., Dec. 16 -- United States Patent no. 12,497,614, issued on Dec. 16, was assigned to Vertex Pharmaceuticals Inc. (Boston).

"Compositions and methods for editing beta-globin for treatment of hemaglobinopathies" was invented by Sanjay D'Souza (Cambridge, Mass.), Jason West (Lexington, Mass.), Brenda K. Eustace (Boston) and Sudipta Mahajan (Boston).

According to the abstract* released by the U.S. Patent & Trademark Office: "The disclosure features systems and methods for correcting a mutation in the human beta-globin (HBB) gene in a cell or population of cells. The disclosure also features methods of increasing repair of a DNA double stranded break (DSB) in an HBB gene by the homology-directed repair (HDR) pathway. The disclos...