US Patent Issued to Vanderbilt University on Oct. 21 for "Positive modulators of the muscarinic acetylcholine receptor M4" (Tennessee Inventors)

ALEXANDRIA, Va., Oct. 28 -- United States Patent no. 12,448,380, issued on Oct. 21, was assigned to Vanderbilt University (Nashville, Tenn.).

"Positive modulators of the muscarinic acetylcholine receptor M4" was invented by Craig W. Lindsley (Brentwood, Tenn.), Darren W. Engers (Brentwood, Tenn.), Kayla J. Temple (Spring Hill, Tenn.), Alison R. Gregro (Mount Juliet, Tenn.), Alexa E. Richardson (Nashville, Tenn.) and Madeline F. Long (Nashville, Tenn.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Deuterium-labeled 4-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)oxy)piperidines substituted with pyrrolo[3,4-b]pyridin-5-one, furo[3,4-b]pyridin-5(7H)-one, or [1,2,4]triazolo[4,3-a]pyrimidin-3(2H)-one are positive alloste...