US Patent Issued to University of Pittsburgh-Of the Commonwealth System of Higher Education on May 6 for "Anaplerotic agents for treatment of disorders of propionate and long chain fat metabolism" (Pennsylvania Inventors)

ALEXANDRIA, Va., June 10 -- United States Patent no. 12,290,500, issued on May 6, was assigned to University of Pittsburgh-Of the Commonwealth System of Higher Education (Pittsburgh).

"Anaplerotic agents for treatment of disorders of propionate and long chain fat metabolism" was invented by Gerard Vockley (Pittsburgh) and Al-Walid A. Mohsen (Pittsburgh).

According to the abstract* released by the U.S. Patent & Trademark Office: "Methods of treating propionic acidemia (PA), methylmalonic acidemia (MMA) and fatty acid oxidation disorders are described. The methods include administering an anaplerotic agent that can directly enter the tricarboxylic acid cycle, such as a succinate derivative or pro-drug, for example trisuccinylglycerol (TSG)....