US Patent Issued to University of Pittsburgh-Of the Commonwealth System of Higher Education on Feb. 3 for "Fluorogenic probe using a Mislow-Evans rearrangement for real-time imaging of hydrogen peroxide" (Pennsylvania Inventor)

ALEXANDRIA, Va., Feb. 3 -- United States Patent no. 12,540,150, issued on Feb. 3, was assigned to University of Pittsburgh-Of the Commonwealth System of Higher Education (Pittsburgh).

"Fluorogenic probe using a Mislow-Evans rearrangement for real-time imaging of hydrogen peroxide" was invented by Kazunori Koide (Pittsburgh).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein is a fluorogenic probe that selectively undergoes a [2,3]-sigmatropic rearrangement (seleno-Mislow-Evans rearrangement) with H2O2, followed by an acetal hydrolysis, to produce a green fluorescent molecule in seconds. Also provided herein is a method of identifying or visualizing the presence of H2O2 in a cell, tissue, organ, or...