ALEXANDRIA, Va., Aug. 26 -- United States Patent no. 12,397,041, issued on Aug. 26, was assigned to UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh).

"Vasoactive intestinal peptide release from microparticles" was invented by Steven R. Little (Pittsburgh) and Andrew Jason Glowacki (Pittsburgh).

According to the abstract* released by the U.S. Patent & Trademark Office: "Controlled release of VIP from PLGA microparticles was accomplished and varied through use of different polymer molecular sizes, addition of solutes to the inner aqueous phase, and use of our computer model. Released VIP from microparticles appeared to be bioactive and caused DCs to produce more CCL22 than DCs treated with blank particles...